Graft Survival Rate of Renal Transplantation: A Single Center Experience, (1999-2009)

Graft Survival Rate of Renal Transplantation: A Single Center Experience, (1999-2009)


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علوم پزشکی اراک
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نویسندگان: امیر الماسی حشیانی

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نشریه: iran red crescent med j, 6,,392 - 397,

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کد مقاله 1706
عنوان فارسی مقاله Graft Survival Rate of Renal Transplantation: A Single Center Experience, (1999-2009)
عنوان لاتین مقاله Graft Survival Rate of Renal Transplantation: A Single Center Experience, (1999-2009)
نوع مقاله بر حسب نگارش پژوهشی اصیل
مقاله برحسب نمایه ISI
IF 0.071
عنوان نشریه iran red crescent med j
نوع نشریه علمی پژوهشی
شماره نشریه 6
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صفحه شروع و پایان در نشریه 392 - 397
سال انتشار/ ارائه شمسی
سال انتشار/ارائه میلادی
آدرس لینک مقاله/ همایش در شبکه اینترنت
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چکیده انگلیسیBackground: Renal transplantation is the best option for treatment of the end-stage renal diseases and has more advantages than dialysis. The objective of this study is to determine the ten-year graft survival rate of renal transplantation and its associated factors in patients who have been transplanted from March 1999 to March 2009 in Nemazee Hospital Transplantation Center. Methods: This is a historical cohort study of 1356 renal transplantation carried out during 1999 to 2009. Kaplan-Meier method was used to determine the survival rate, log rank test to compare survival curves, and Cox regression model to determine hazard ratios and for modeling of variables affecting survival. Results: The 1, 3, 5, 7 and 10 years graft survival rates were 96.6, 93.7, 88.9, 87.1 and 85.5 percent, respectively. Cox regression model revealed that the donor source and creatinine level at discharge were effective factors in graft survival rate in renal transplantation. Conclusion: Our study showed that 10 year graft survival rate for renal transplantation in Nemazee Hospital Transplantation Center was 85.5% and graft survival rate was significantly related to recipients and donor’s age, donor source and creatinine level at discharge. Our experience in renal transplantation survival rate indicates a success rate comparable to those noted in other reports. Keywords: Renal transplantation; Graft survival; Cox regression model; Iran Manuscript Body: nephrologists and recorded in follow-up clinics and related institutions such as "Management Center for Transplantation and Special Diseases" and "Renal Patients Support Society". Allograft survival rate was calculated by Kaplan-Meier method and Log-rank test was used to compare survival curves and Cox Regression Models to define the hazard ratio and for modeling of factors implicating in survival rate. The SPSS® software (version16, Chicago, IL, USA) and STATA (version 9 for assessment proportionality of hazard ratio assumption) were used for statistical analysis of data. The P-value of less than 0.05 was considered to be statistically significant. Results One thousands and three hundred and fifty six cases of kidney transplantation were performed in Shiraz Transplant Center, Nemazee Hospital, during a period of 10 years (1999-2009). Out of these, 403 (29.7%) kidneys were from living related donors, 441 (32.5%) kidneys from living unrelated donors and 512 (37.8%) kidneys from deceased donors. We could follow 1288 (94.9%) out of 1356 patients who had received kidney and found that 107 (7.9%) of them had been eventuated in irreversibly non-functioning allografts that necessitated regular dialysis again. The mean age of kidney donors and recipients were 34.99±13.94 and 31±11.21 years, respectively. The mean duration of hospital stay and duration of dialysis before operation were 12.29±5.63 days and 15.93±14.52 months, respectively, and mean follow-up period was 47.23±33.33 months. The age of donors and recipients in 94.5 and 84.2% of cases were less than 50 years old, respectively. 64.4 percent of recipients were male and 35.6% were female. The males and females comprised 65.9 and 34.1% of donors respectively, and 41.7% of transplantations were performed from male to male. Blood type of “O” has been the most frequent blood type among recipients and donors with 43.3 and 50.4% of cases respectively, and blood group and Rh of donor and recipient in 85% of cases were identical. Considering creatinine level status at discharge, in 85.5% of recipients was 2 mg/dl or less. Warm and cold ischemia time in 100 and 57.6% of cases were less than 2 hours, respectively. Endarterectomy was not performed in 92.1% of cases and in 92.3% of cases; the first time to urination was immediate. In 61.7% of cases, the duration of hospitalization after operation was from 7 to 14 days. The underlying cause of ESRD was mostly unknown (comprising 53.9% of cases). However, the most common diagnosed renal disease leading to ESRD was glomerulonephritis (in 27.7% of cases). The first regimen was the most frequently used immunosuppressive therapy which had been administered in nearly 49.3% of cases. As shown in Figure 1, the calculated survival rate of 1, 3, 5, 7, 10 year for renal transplantation using Kaplan-Meier method was 96.6, 93.7, 88.9, 87.1 and 85.5%, respectively. For investigating the existence of any significant difference among the different classes of these variables from the point of survival rate, Log-rank method calculated p-values, have been calculated and age of donor (p=0.005), donor source (p=0.001), HCV infection (p=0.029), creatinine level at discharge (p=0.001), and duration of hospitalization after operation (p=0.017) showed significant relationship with renal transplantation graft survival rate. In the other variables, there was no significant difference among their graft survival curves. Using Cox proportional hazard model that was shown in Table 1, we found that donor source and creatinine level at discharge (as shown in Figure 2 and 3) had a significant relationship with graft survival rate. Hazard ratio in deceased-donor transplantation compared to living-related donor has been 2.56 (CI=1.36–4.78, p=0.003). Also, in the cases which discharge time, the creatinine level was more than 2 mg/dl in comparison to cases with creatinine level of 2 mg/dl or less and a hazard ratio of 3.97 (CI=2.3–6.8, p=0.001). Discussion In this study, the survival rate of 1, 3, 5, 7, and 10- years have been 96.6, 93.7, 88.9, 87.1, and 85.8% respectively. According to the report of Iranian Network for Organ Procurement, one- year survival rate in Iran taps around 95%, a result which is similar to our study. Using Kaplan-Meier method, the age of donor has been known as one of the contributor factor on survival rate. A lot of studies have been conducted upon above mentioned issue which some of them are studies of Briganti11 and Orsenigo et al.,12 which showed that the age of donor and recipient are of contributing variables. These results have been confirmed by plenty of other studies,13-17 but using Cox proportional hazard model we found that the age of donors and recipients were not significant with graft survival rate of renal transplantation. Many studies have shown that there is no significant relationship between the gender of graft donor and recipient with survival rate of transplantation11,13,17 and our study is another evidence for this correlation. One of the effective variables on survival rate which also has been studied,11,13 is the donor source (living- related donor, living- unrelated donor and deceased-donor). In this study, this factor was also determined and revealed that the living- donor survival rate is significantly higher in comparison with deceased donor. Albeit that is true, using deceased organs is one of the major strategies for shortening the waiting time for transplantation, following that, the time of pre- operation dialysis which can be one of the important factors on survival rate decreases. Briganti et al.,11 Mohamed et al.,16 and Bruce Kaplan et al.,14 reported that the increase of cold ischemia time leads to the decrease of transplantation survival rate significantly. On the other hand in the study that Courtney et al.13 conducted, there was no significant relationship between survival rate and cold ischemia time which is similar to our study findings. One of the reasons for differences in observed results might be the incomplete registration of cold ischemia time in our study, since in this study, only in 55.3% of cases, cold ischemia time was etermined. In many studies, the graft and patient’s survival rate in HCV positive and negative groups has been reported equal.18-21 On the other hand, in some studies the graft survival rate for HCV negative cases in comparison to HCV positive cases have been significantly higher,16,22 and this study also confirms that graft survival rate in different HCV donors group was not significant. In this study, the graft survival rate between different occupational groups was not significant. Also, having or not having the history of endarterectomy, iliac type of vein and artery and the number of used veins and arteries (simple, double and triple) have not shown significant relationship with survival rate. A lot of studies, including Courtney et al.'s study,13 have shown that the cause of ESRD is one of those factors that have this potential to influence the graft survival rate of kidney transplantation. On the other hand some reports have represented that there is no significant relationship between survival rate and the cause of ESRD.11,23, 24 In this study, there was no significant relationship between survival rate and primary renal disease too, albeit this should be mentioned that in over the 50% of the cases (53.9%) the reason of ESRD was not clear. Cox regression model demonstrated that duration of dialysis before operation had no significant relationship with the survival rate and this finding is similar to other results.25 On the other hand, in some reports, there was a significant correlation between graft survival rate of transplantation and duration of dialysis before operation.11,26 The right or left being of donor kidney was from those variables which had not significant relationship with survival rate. In most cases, the left kidney because of having a longer vein was selected for transplantation and in this study composed 98% of the cases among whom, the left or right side of kidney was known. The duration of post-operation hospitalization is another independent variable which had influence on the survival rate while in the final model had no significant relationship with survival rate. In recent years, there has been a descending trend in the period of patient hospitalization and in the recent decade, the period of hospitalization in renal transplantation has decreased from 12.7-19 days to 5-7.5.27,28 Lin’s study showed that less than 4 days hospitalization would be one of the possible effective factors of the reduction of survival rate and patient survival in the long run.28 In recent years, the progress in immunosuppressive regimen has led to improvement of transplantation survival rate and patient’s survival rate, but in this study, no significant relationship between immunosuppressive drug regimen and graft survival rate was noticed and also in other studies, there was no association between immunosuppressive regimen and the survival rate.26,27,29 Creatinine level at discharge was another variable which showed a significant relationship with the survival rate of kidney transplantation on Cox model which is similar to Rayhill's et al.'s study,30 Based on Rayhill's et al.'s study, per one singular unit increased the creatinine level and the transplantation risk ratio increased 1.8 times. Our study showed that 10 year graft survival rate for renal transplantation in Nemazee Hospital Transplantation Center was 85.5% and graft survival rate was significantly related to recipients and donor’s age, donor source and creatinine level at discharge. Our experience in renal transplantation survival rate indicates a success rate comparable to those noted in other reports. Acknowledgments: With especial thanks to Dr. Farzad Kakaee and Mr. Esmaeil Khedmati to their helps. Conflict of interest: None declare References: (30) Abbaszadeh S, Nourbala MH, Taheri S, Ashraf A, Einollahi B. Renal transplantation from deceased donor in Iran. Saudi J Kidney Dis Transpl 2008;19:664-8. [18580034] Haghighi AN, Broumand B, D'Amico M, Locatelli F, Ritz E. The epidemiology of end- stage renal disease in Iran in an international perspective. Nephrol Dial Transplant 2002;17:28-32. [11773458] [doi:10.1093/ndt/17.1.28] Abboud O. Incidence, prevalence and treatment of End Stage Renal Disease in the Middle East. Ethn Dis 2006;16:S2-2-4. [16774000] Mahdavi-Mazdeh M, Heidary-Rouchi A, Aghighi M, Rajolani H. Organ and tissue transplantation in Iran. Saudi J Kidney Dis Transpl 2008;19:127-31. [18087142] Mahdavi-Mazdeh M, Heidary Rouchi A, Norouzi S, Aghighi M, Rajolani H, Ahrabi S. Renal Replacement therapy in Iran. Urol J 2007;4:66-70. [17701924] Schena FP. Epidemiology of End Stage Renal Disease: International comparisons of Renal Replacement therapy. Kidney International 2000;57:S39-S45. [doi:10.1046/j.1523-1755.2000.07407.x] Hariharan S, Johnson CP, Barbara BA, Taranto SE, McIntosh MJ, Stablein D. Improved graft survival after renal transplantation in the United States, 1988 to 1996. N Engl J Med 2000;342:605-12. [10699159] [doi:10.1056/NEJM200003023420901] Cacho DT, Cusí LI, Piqué AA, Villar PB, Reyes LI, Alvarez-Vijande García R, Salinas FO, del Pozo RG. Elderly donor kidney transplant: factors involved in graft survival. Transplant Proc 2005;37:3690-2. [16386507] [doi:10.1016/j.transproceed.2005.10.071] Meier-Kriesche HU, Port FK, Ojo AO, Rudich SM, Hanson JA, Cibrik DM, Leichtman AB, Kaplan B. Effect of waiting time on renal transplant out come. Kidney Int 2000;58:1311-7. [10972695] [doi:10.1046/j.1523-1755.2000.00287.x] Shrestha BM, Haylor JL. Factors influencing long term outcome following renal transplantation: A review. J Nepal Med Assoc 2007;46:136-42. [18274571] Briganti EM, Wolfe R, Russ GR, Eris JM, Walker RG, McNeil JJ. Graft loss following renal transplantation in Australia: Is there a center effect? Nephrol Dial Transplant 2002;17:1099-104. [12032203] [doi:10.1093/ndt/17.6.1099] Orsenigo E, Socci C, Carlucci M, Zuber V, Fiorina P, Gavazzi F, Secchi A, Di Carlo V, Staudacher C. Multivariate analysis of factors affecting patient and graft survival after renal transplant. Transplant Proc 2005;37:2461-3. [16182709] [doi:10.1016/j.transproceed.2005.06.099] Courtney AE, MC namee PT, Maxwell AP. The evolution of renal transplantation in clinical practice: for better, for worse? QJM 2008;101:967-78. [18927195] [doi:10.1093/qjmed/hcn136] Kaplan B, Schold JD, Meier-Kriesche HU. Long term graft survival with Neoral and Tacrolimus: A Paired Kidney Analysis. J Am Soc Nephrol 2003;14:2980-4. [14569110] [doi:10.1097/01.ASN.0000095250.92361.D5] Pugliese O, Quintieri F, Mattucci DA, Venettoni S, Taioli E, Costa AN. Kidney graft survival in Italy and factors influencing it. Prog Transplant 2005;15:385-91. [16477822] Bakr MA, Ghoneim MA. Living donor renal transplantation, 1976-2003: The Mansoura Experience. Saudi J Kidney Dis Transpl 2005;16:573-83. [18202512] Feyssa E, Jones-Burton C, Ellison G, Philosophe B, Howell C. Racial/ethnic disparity in kidney transplantation outcomes: influence of donor and recipient characteristics. J Natl Med Assoc 2009;101:111-5. [19378626] Meier-Kriesche HU, Ojo AO, Hanson JA, Kaplan B. Hepatitis C antibody status and outcome in renal transplant recipients. Transplantation 2001;72:241-4. [11477346] [doi:10.1097/00007890-200107270-00013] Hestin D, Guillemin F, Castin N, Le Faou A, Champigneulles J, Kessler M. Pretransplantation Hepatitis C virus infection :a predictor of proteinuria after renal transplantation. Transplantation 1998;65:741-4. [9521213] [doi:10.1097/00007890-199803150-00024] Shahbazian H, Hajiani E, Ehsanpour A. Patient and graft survival oh allograft recipients with minimal hepatitis C virus infection a case control study. Urol J 2008;5:178-83. [18825625] Einollahi B, Hajarizadeh B, Bakhtiari S, Lesanpezeshki M, Khatami MR, Nourbala MH, Pourfarziani V, Alavian SM. Pre-transplant hepatitis C virus infection and its effect on the post-transplant course of living renal allograft recipients. J Gastroenterol Hepatol 2003;18:836-40. [12795757] [doi:10.1046/j.1440-1746.2003.03063.x] Mitwalli AH, Alam A, Al-Wakeel J, Al Suwaida K, Tarif N, Schaar TA, Al Adbha B, Hammad D. Effect of Chronic Viral Hepatitis on Graft Survival in Saudi Renal Transplant Patients. Nephron Clin Pract 2006;102:c72-80. [16244496] [doi:10.1159/000089090] El-Husseini AA, Foda MA, Shokeir AA, Shehab El-Din AB, Sobh MA, Ghoneim MA. Determinants of graft survival in paediatric and adolescent live donor kidney transplant recipients: A single center experience. Pediatr Transplant 2005;9:763-9. [16269048] [doi:10.1111/j.1399-3046.2005.00376.x] El-Husseini AA, Mohamed A F, Mohamed AB, Shokeir AA, Sobh MA, Ghoneim MA. Paediatric live-donor kidney transplantation in Mansoura Urology& Nephrology Center: a 28-year perspective. Pediatr Nephrol 2006;21:1464-70. [16791608] [doi:10.1007/s00467-006-0150-2] Resende L, Guerra J, Santana A, Mil-Homens C, Abreu F, da Costa AG. Influence of Dialysis Duration and Modality on Kidney Transplant Outcomes. Transplant Proc 2009;41:837-9. [19376365] [doi:10.1016/j.transproceed.2009.01.063] Mange KC, Joffe MM, Feldman HI. Effect of the use or non-use of long term dialysis on the subsequent survival of renal transplantation from living donor. N Engl J Med 2001;344:726-31. [11236776] [doi:10.1056/NEJM200103083441004] Shapiro R, Jordan ML, Scantlebury VP, Vivas C, Gritsch HA, Fox-Hawranko L, Doyle HR, Johnson LB, Fenton R, Painter L, Keefer-Wolf K, Redman C, McCauley J, Fung JJ, Hakala TR, Starzl TE, Simmons RL. Reducing the length of stay after kidney transplantation – the intensive outpatient unit. Clin Transplant 1998;12:482-5. [9787961] Lin SJ, Koford JK, Baird BC, Habib AN, Reznik I, Chelamcharla M, Shihab FS, Goldfarb-Rumyantzev AS. The association between length of post-kidney transplant hospitalization and long-term graft and recipient survival. Clin Transplant 2006:20:245-52. [16640534] [doi:10.1111/j.1399-0012.2005.00476.x] Opelz G. Immunosuppression with FK506 does not improve kidney graft survival. Transplant Proc 1999;31:147-8. [doi:10.1016/S0041-1345(98)01940-X] Rayhill SC, D'Alessandro AM, Odorico JS, Knechtle SJ, Pirsch JD, Heisey DM, Kirk AD, Van der Werf W, Sollinger HW. Simultaneous Pancreas-Kidney Transplantation and Living Related Donor Renal Transplantation in Patients With Diabetes: Is There a Difference in Survival? Ann Surg 2000;231:417-23. [10714635] [doi:10.1097/00000658-200003000-00015]
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