.Helicobacter pylori Seropositivity in Children With Asthma

.Helicobacter pylori Seropositivity in Children With Asthma


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نویسندگان: محمد رفیعی , منیژه کهبازی , قاسم مسیبی , پارسا یوسفی چایجان , مجتبی شرفخواه , فائزه حیدربیگی

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نشریه: Archives of Pediatric Infectious Diseases, 1,4,1 - 5,2016

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کد مقاله 2129
عنوان فارسی مقاله .Helicobacter pylori Seropositivity in Children With Asthma
عنوان لاتین مقاله .Helicobacter pylori Seropositivity in Children With Asthma
نوع مقاله بر حسب نگارش پژوهشی اصیل
مقاله برحسب نمایه scopus
IF 0.0
عنوان نشریه Archives of Pediatric Infectious Diseases
نوع نشریه علمی پژوهشی
شماره نشریه 1
دوره 4
صفحه شروع و پایان در نشریه 1 - 5
سال انتشار/ ارائه شمسی 1394
سال انتشار/ارائه میلادی 2016
آدرس لینک مقاله/ همایش در شبکه اینترنت http://pedinfect.com/?page=article&article_id=26639
ISSN 2322-1828
DOI DOI: 10.5812/pedinfect.26639
آدرس علمی (Affiliation) نویسنده متقاضی Department of Pediatric Nephrology, Arak University of Medical Sciences, Arak, IR Iran

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چکیده انگلیسیHelicobacter pylori Seropositivity in Children With Asthma ________________________________________ Parsa Yousefichaijan 1 ; Ghasem Mosayebi 2 ; Mojtaba Sharafkhah 3, * ; Manijeh Kahbazi 4 ; Phaezeh Heydarbagi 3 ; and Mohammad Rafiei 5 1 Department of Pediatric Nephrology, Arak University of Medical Sciences, Arak, IR Iran 2 Department of Immunology, Arak University of Medical Sciences, Arak, IR Iran 3 Students Research Committee, School of Medicine, Arak University of Medical Sciences, Arak, IR Iran 4 Department of Pediatric, Arak University of Medical Sciences, Arak, IR Iran 5 Department of Biostatistics and Epidemiology, Arak University of Medical Sciences, Arak, IR Iran Abstract Background: Some studies have reported an association between Helicobacter pylori (H. pylori) colonization and the occurrence of asthma or other allergies. However, data are inconsistent, and few studies have been performed in children. Objectives: The current study aimed to investigate H. pylori seropositivity in children with and without asthma. Patients and Methods: This cross-sectional study was performed with 208 children aged 5- to 12-years-old (104 asthmatic subjects in the case group and 104 healthy individuals in the control group) who had been referred to the pediatric clinic of Amir Kabir hospital in Arak, Iran. H. pylori seropositivity was compared between the two groups according to the serum level of immunoglobulin G (IgG) antibody against the H. pylori cytotoxin-associated gene A (CagA) protein, which was measured using the enzyme-linked immunosorbent assay (ELISA). Results: The H. pylori serology test was positive in 13 (12.5%) asthmatic subjects and 18 (17.3%) healthy subjects. This difference was not significant (P = 0.54). Duration of asthma in the serology-positive children (3.61 ± 1.5 years) was significantly higher than that of the serology-negative children (2.16 ± 1.33 years) (P = 0.0001). No significant correlations were found between H. pyloriseropositivity and age (P = 0.95), gender (P = 0.7), severity of asthma (P = 0.54), control of the asthma (P = 0.23), or pulmonary function test (PFT) results (P = 0.23). Conclusions: The results showed no association between childhood asthma and H. pylori seropositivity. However, due to the lack of studies, especially in children, and controversial results of the clinical studies, further studies are recommended. Keywords: Asthma; Child; Helicobacter pylori
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نویسنده نفر چندم مقاله
محمد رفیعیششم
منیژه کهبازیچهارم
قاسم مسیبیدوم
پارسا یوسفی چایجاناول
مجتبی شرفخواهسوم و مسئول
فائزه حیدربیگیپنجم

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