Merkel cell polyomavirus and human papillomavirus infections in cervical disease in Iranian women

Merkel cell polyomavirus and human papillomavirus infections in cervical disease in Iranian women


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پژوهان
صفحه نخست سامانه
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چکیده مقاله
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علوم پزشکی اراک
علوم پزشکی اراک

نویسندگان: امیر الماسی حشیانی

کلمات کلیدی:

نشریه: Archives of Virology, 5,160,1181 - 1187,2015

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کد مقاله 2878
عنوان فارسی مقاله Merkel cell polyomavirus and human papillomavirus infections in cervical disease in Iranian women
عنوان لاتین مقاله Merkel cell polyomavirus and human papillomavirus infections in cervical disease in Iranian women
نوع مقاله بر حسب نگارش پژوهشی اصیل
مقاله برحسب نمایه ISI
IF 2.39
عنوان نشریه Archives of Virology
نوع نشریه علمی پژوهشی
شماره نشریه 5
دوره 160
صفحه شروع و پایان در نشریه 1181 - 1187
سال انتشار/ ارائه شمسی 1394
سال انتشار/ارائه میلادی 2015
آدرس لینک مقاله/ همایش در شبکه اینترنت http://www.ncbi.nlm.nih.gov/pubmed/?term=Merkel+cell+polyomavirus+and+human+papillomavirus+infections+in+cervical+disease+in+Ira
ISSN 0304-8608
DOI DOI 10.1007/s00705-015-2368-4
آدرس علمی (Affiliation) نویسنده متقاضی Department of Epidemiology, School of Health, Arak University of Medical Sciences, Arak, Iran

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چکیده انگلیسیMerkel cell polyomavirus and human papillomavirus infections in cervical disease in Iranian women. Salehi-Vaziri M1, Sadeghi F, Alamsi-Hashiani A, Haeri H, Monavari SH, Keyvani H. • 1Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. • Department of Epidemiology, School of Health, Arak University of Medical Sciences, Arak, Iran Abstract Human papillomavirus (HPV) infection is a necessary cause of cervical neoplasia. Concomitant infection with other infectious agents has been demonstrated to be a cofactor for HPV-related cervical carcinogenesis. The present investigation aimed to determine the prevalence of HPV andMerkel cell polyomavirus (MCPyV) infections and to evaluate the role of MCPyV as a co-factor for HPV-related cervical carcinogenesis in Iranianwomen. From 2011 to 2013, a total of 112 cervical samples were examined. Forty-five samples (40.2 %) were positive for HPV. MCPyV was found in 37 samples (33 %). Both HPV and MCPyV were present in 14 samples (12.5 %). MCPyV was seen in 30 % of squamous cellcarcinomas, 37.5 % of adenocarcinomas, and 16.7 % of undifferentiated carcinomas. The MCPyV large T antigen (LT-Ag) DNA load was determined as the viral copy number per cell. The median MCPyV LT-Ag copy number in positive women was 0.049 × 10(-3) per cell (range 0.0006 × 10(-3)-4.558 × 10(-3) copies per cell). In comparison with other types of cervical cancer, the MCPyV LT-Ag load was higher in adenocarcinomas (0.1024 × 10(-3) copies per cell). A logistic regression model adjusted to HPV positivity and age revealed no statistically significant association between MCPyV infection and cervical cancer (OR, 1.12; 95 % CI, 0.07-16.83). More studies should be conducted to clarify the role of MCPyV in cervical carcinogenesis.
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نویسنده نفر چندم مقاله
امیر الماسی حشیانیسوم

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2787متن کامل مقاله1393/12/11388707دانلود