.Genotyping of vancomycin resistant enterococci in arak hospitals

.Genotyping of vancomycin resistant enterococci in arak hospitals


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علوم پزشکی اراک
علوم پزشکی اراک

نویسندگان: حمید ابطحی , مجید اکبری , معصومه صوفیان , مانا شجاع پور

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نشریه: Jundishapur Journal of Microbiology, 4,8,1 - 4,2015

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کد مقاله 3087
عنوان فارسی مقاله .Genotyping of vancomycin resistant enterococci in arak hospitals
عنوان لاتین مقاله .Genotyping of vancomycin resistant enterococci in arak hospitals
نوع مقاله بر حسب نگارش پژوهشی اصیل
مقاله برحسب نمایه ISI
IF 0.655
عنوان نشریه Jundishapur Journal of Microbiology
نوع نشریه علمی پژوهشی
شماره نشریه 4
دوره 8
صفحه شروع و پایان در نشریه 1 - 4
سال انتشار/ ارائه شمسی 1394
سال انتشار/ارائه میلادی 2015
آدرس لینک مقاله/ همایش در شبکه اینترنت http://apps.webofknowledge.com/full_record.do?product=UA&search_mode=GeneralSearch&qid=16&SID=V2wm4ESxyPc5pqab2W3&page=1&doc=1
ISSN 2008-3645
DOI 10.5812/jjm.8(4)2015.16287
آدرس علمی (Affiliation) نویسنده متقاضی Molecular and Medicine Research Center, Arak University of Medical Sciences, Arak, IR Iran

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چکیده انگلیسیGenotyping of Vancomycin Resistant Enterococci in Arak Hospitals By:Zadeh, AH (Zadeh, Adeleh Hoseini)[ 1 ] ; Shojapour, M (Shojapour, Mana)[ 2 ] ; Nazari, R (Nazari, Raziyeh)[ 1 ] ; Akbari, M (Akbari, Majid)[ 2 ] ; Sofian, M (Sofian, Masumeh)[ 3 ] ; Abtahi, H (Abtahi, Hamid)[ 2 ] 1Department of Microbiology, Qom Branch, Islamic Azad University, Qom, IR Iran 2Molecular and Medicine Research Center, Arak University of Medical Sciences, Arak, IR Iran 3Department of Infectious Diseases, Arak University of Medical Sciences, Arak, IR Iran *Corresponding author: Hamid Abtahi, Molecular and Medicine Research Center, Arak University of Medical Sciences, Arak, IR Iran. Tel: +98-8634173502, Fax: +98-8634173526, E-mail: abtahi@arakmu.ac.ir Abstract Background: Enterococcal species have emerged as important pathogens in Iran as well as throughout the world. With the increased use of vancomycin, Vancomycin-Resistant Enterococci (VRE) has become an important nosocomial pathogen. Objectives: The aim of the present study was to determine the incidence and antimicrobial susceptibility pattern of VRE and also to determine the most important genes that cause resistance to vancomycin in clinical samples in Arak, Iran. Materials and Methods: In total, 200 enterococci samples were collected from clinical specimens of Arak hospitals. Enterococcal species were identified using standard biochemical tests. Antibiotic susceptibility was tested by the Clinical and Laboratory Standards Institute (CLSI) disk diffusion. Minimum Inhibitory Concentration (MICs) was determined by broth micro dilution. All of the VRE isolates were examined by PCR to detect the presence of VRE genes. Results: Disk diffusion agar showed that 96 strains (48%) were resistant to gentamicin, 89 (44.5%) to ciprofloxacin, 127 (63.5%) to erythromycin, 142 (71%) to tetracycline, 11 (5.5%) to teicoplanin, 32 (16%) to vancomycin, none to linezolid and 96 (48%) to co-trimoxazole. The MICs of the resistant isolates were as follows; 88 strains had MIC >= 32 mu g/mL to vancomycin and 59 strains had MIC >= 32 mu g/mL to teicoplanin. Molecular studies revealed that 59.09% of VRE contained VanA genes and 7.95% of VRE contained the VanB genes. None of the strains had vanC1 and vanC2/3 gene. Conclusions: According to the results of this study, rates of vancomycin-resistance in enterococci, in Iran like other parts of the world, is increasing. Therefore accurate methods are required for identifying strains that possess resistance genes because many cases of hospital infections are caused by these strains. Keywords:Vancomycin; Vancomycin-Resistant Enterococci; VanB protein
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نویسنده نفر چندم مقاله
حمید ابطحیششم و مسئول
مجید اکبریچهارم
معصومه صوفیانپنجم
مانا شجاع پوردوم

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abtahi.pdfمتن کامل مقاله1394/03/09284518دانلود