.Serum Zinc, Copper, Iron, and Magnesium Levels in Iranian Drug Users: A Case Control Study

.Serum Zinc, Copper, Iron, and Magnesium Levels in Iranian Drug Users: A Case Control Study


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علوم پزشکی اراک
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نویسندگان: محمد رفیعی , حسن صلحی , علی قضاوی , قاسم مسیبی , احمد اکبری , اعظم اسدی

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نشریه: Journal of Addiction Medicine, 4,9,304 - 307,2015

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کد مقاله 2929
عنوان فارسی مقاله .Serum Zinc, Copper, Iron, and Magnesium Levels in Iranian Drug Users: A Case Control Study
عنوان لاتین مقاله .Serum Zinc, Copper, Iron, and Magnesium Levels in Iranian Drug Users: A Case Control Study
نوع مقاله بر حسب نگارش پژوهشی اصیل
مقاله برحسب نمایه ISI
IF 1.756
عنوان نشریه Journal of Addiction Medicine
نوع نشریه علمی پژوهشی
شماره نشریه 4
دوره 9
صفحه شروع و پایان در نشریه 304 - 307
سال انتشار/ ارائه شمسی 1394
سال انتشار/ارائه میلادی 2015
آدرس لینک مقاله/ همایش در شبکه اینترنت http://www.ncbi.nlm.nih.gov/pubmed/26125147
ISSN 1932-0620
DOI doi: 10.1097/ADM.0000000000000134
آدرس علمی (Affiliation) نویسنده متقاضی Department of Immunology, School of Medicine (AG), Arak University of Medical Sciences, Arak, Iran

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چکیده انگلیسیSerum Zinc, Copper, Iron, and Magnesium Levels in Iranian Drug Users: A Case Control Study. Akbari A1, Mosayebi G, Solhi H, Rafiei M, Asadi A, Ghazavi A. • 1From the Arak University of Medical Sciences, Arak, Iran (A. Akbari and A. Asadi); Molecular and Medicine Research Center, • Department of Immunology, School of Medicine (GM), Department of Forensic Medicine & Toxicology (HS), • Department of Biostatistics and Epidemiology (MR), and Tuberculosis and Pediatric Infectious Research Center (TPIRC), • Department of Immunology, School of Medicine (AG), Arak University of Medical Sciences, Arak, Iran. Abstract INTRODUCTION: The changes in concentration of trace elements have effects on many organ systems, including the immune system. There have been conflicting reports on serum trace element levels in heroin users. This study was carried out to compare serum trace element concentrations in opium, heroin, and methamphetamine users. METHODS: The study was done on 90 chronically illegal drug users (n = 30 per group) and 30 controls of the similar sex and age range (from 20 to 40 years). The control group was healthy subjects with no lifetime history of substance abuse or dependence. All of the substance users were selected from among those who had a history of substance use, for a minimum of 1 year. Serum zinc (Zn), copper (Cu), iron (Fe), and magnesium (Mg) were measured spectrophotometrically using chemistry analyzer. RESULTS: Serum Fe concentration was decreased in heroin (P = 0.026) and methamphetamine (P = 0.0001) users compared with healthy subjects, whereas serum Cu was higher in opium, heroin, and methamphetamine users (P < 0.01). Copper was negatively and significantly correlated with Fe in all groups (P < 0.05). There was no statistically significant difference between drug users and healthy subjects in serum concentrations of Zn and Mg. CONCLUSIONS: This study showed decreased in serum concentration of iron and increase in serum copper in drug users when compared with controls.
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نویسنده نفر چندم مقاله
محمد رفیعیچهارم
حسن صلحیسوم
علی قضاویششم و مسئول
قاسم مسیبیدوم
احمد اکبریاول
اعظم اسدیپنجم

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