Comparing the analgesic effect of intranasal with intravenous ketamine in isolated orthopedic trauma: A randomized clinical trial.

Comparing the analgesic effect of intranasal with intravenous ketamine in isolated orthopedic trauma: A randomized clinical trial.


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پژوهان
صفحه نخست سامانه
چکیده مقاله
چکیده مقاله
نویسندگان
نویسندگان
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علوم پزشکی اراک
علوم پزشکی اراک

نویسندگان: رامین پرویزراد , امیر الماسی حشیانی , بیتا ملکیان زاده , عبدالقادر پاک نیت

کلمات کلیدی: KEYWORDS: Emergency; Intranasal; Ketamine; Pain

نشریه: ---- عنوان نشریه در لیست موجود نیست ----, 3,,99 - 103,2017

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کد مقاله 4125
عنوان فارسی مقاله Comparing the analgesic effect of intranasal with intravenous ketamine in isolated orthopedic trauma: A randomized clinical trial.
عنوان لاتین مقاله Comparing the analgesic effect of intranasal with intravenous ketamine in isolated orthopedic trauma: A randomized clinical trial.
نوع مقاله بر حسب نگارش پژوهشی اصیل
مقاله برحسب نمایه ISI
IF
عنوان نشریه Turkish Journal of Emergency Medicine
نوع نشریه علمی پژوهشی
شماره نشریه 3
دوره 17
صفحه شروع و پایان در نشریه 99 - 103
سال انتشار/ ارائه شمسی 1396
سال انتشار/ارائه میلادی 2017
آدرس لینک مقاله/ همایش در شبکه اینترنت
ISSN 2452-2473
DOI
آدرس علمی (Affiliation) نویسنده متقاضی r.parvizrad@arakmu.ac.ir.Department of Emergency Medicine, School of Medicine, Arak University of Medical Sciences, Arak, Iran

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عنوان متن
چکیده انگلیسیAbstract OBJECTIVES: Ketamine is commonly used in anesthetic and sedation before surgical procedures and acts as an analgesic in smaller doses. The aim of this study was to assess the effects of intranasal (IN) ketamine in patients with moderate to severe limb trauma (visual analog scale (VAS) > 60 mm). METHODS: In a triple-blind randomized controlled clinical trial; 154 patients with isolated orthopedic trauma and visual analog scale (VAS) ≥60 mm were included on the basis of inclusion and exclusion criteria. Patients were divided into two groups of ketamine-IN (0.4 mg/kg IN ketamine and an equal volume of placebo saline intravenously (IV)) and ketamine-IV (0.2 mg/kg ketamine IV with 0.5 ml saline IN) on the basis of balanced block randomization method. At 5, 10, 20, and 30 min, patients were assessed for VAS measurement and adverse events. Repeated measure ANOVA, independent t-test and chi square test were employed. The level of statistical significance was considered to be less than 0.05. RESULTS: Mean VAS in IN ketamine and IV group at minute 30 was 31.50 ± 13.40 and 29.35 ± 11.73, respectively. At minute 30, 31 patients (20.39%) required a low-dose of morphine as rescue analgesia (P = 0.427). The results showed that mean change score of VAS (difference of time 0 and time 30) in IN ketamine and IV ketamine VAS were 43.8 (95% confidence interval: 41.1-46.5) and 46.4 (95% confidence interval: 42.8-50.1) and there is no difference between two groups in case of score change of VAS (P = 0.245). Adverse events in nasal and intravenous ketamine in both groups were mild and transient. CONCLUSION: IN ketamine is associated with few side effects and appropriate analgesic effects in isolated orthopedic trauma patients, and it may be used in cases where there is no need for venipuncture of peripheral vessels, especially in crowded EDs.
چکیده
کلمات کلیدیKEYWORDS: Emergency; Intranasal; Ketamine; Pain
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نویسنده نفر چندم مقاله
رامین پرویزراداول
امیر الماسی حشیانیچهارم
بیتا ملکیان زادهسوم
عبدالقادر پاک نیتدوم

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