Anti-cancer effects of Staphylococcal Enterotoxin type B on U266 cells cocultured with Mesenchymal Stem Cells

Anti-cancer effects of Staphylococcal Enterotoxin type B on U266 cells cocultured with Mesenchymal Stem Cells


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علوم پزشکی اراک
علوم پزشکی اراک

نویسندگان: علی قضاوی , قاسم مسیبی

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نشریه: Microbial Pathogenesis, 0882-4010,,438 - 444,2017

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کد مقاله 4205
عنوان فارسی مقاله Anti-cancer effects of Staphylococcal Enterotoxin type B on U266 cells cocultured with Mesenchymal Stem Cells
عنوان لاتین مقاله Anti-cancer effects of Staphylococcal Enterotoxin type B on U266 cells cocultured with Mesenchymal Stem Cells
نوع مقاله بر حسب نگارش پژوهشی اصیل
مقاله برحسب نمایه ISI
IF 2.009
عنوان نشریه Microbial Pathogenesis
نوع نشریه علمی پژوهشی
شماره نشریه 0882-4010
دوره 113
صفحه شروع و پایان در نشریه 438 - 444
سال انتشار/ ارائه شمسی 1396
سال انتشار/ارائه میلادی 2017
آدرس لینک مقاله/ همایش در شبکه اینترنت https://www.sciencedirect.com/science/article/pii/S088240101731375X
ISSN 0882-4010
DOI doi.org/10.1016/j.micpath.2017.11.024
آدرس علمی (Affiliation) نویسنده متقاضی bDepartment of Microbiology and Immunology, School of Medicine, Arak University of Medical Sciences, Arak, Iran

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عنوان متن
چکیده انگلیسیMalignant plasma cells are responsible for Multiple Myeloma (MM). Myeloma Cells (MCs) are located in Bone Marrow (BM) and are in contact with stromal cells. The BM-derived Mesenchymal Stem Cells (BM-MSCs) affect MCs biology through different mechanisms. Currently, Staphylococcal Enterotoxin B (SEB) has been introduced as an anti-tumor agent that is able to kill cancer cells. The present study examined the effects of SEB on MCs and MSCs as an anti-tumor substance.U266 cells co-cultured on BM-MSCs and treated with SEB and cell viability was analyzed by MTT assay and flow cytometry. The expression levels of IKKb, IL-6, IL-10, and TGF-β genes were evaluated by Real Time-PCR technique in U266 cells and BM-MSCs.Data showed that in the presence of SEB, BM-MSCs support U266 cells proliferation and survival. Moreover, SEB, BM-MSCs and BM-MSCs Conditioned Medium (CM) up-regulated IL-6 and IL-10 expression in U266 cells. Additionally, U266 cells showed increased levels in IKKb expression in presence of SEB or BM-MSCs, while expression of IKKb in U266 cells was down-regulated in coexistence of SEB with BM-MSCs or SEB with CM. Also, TGF-β remained without any changes.All in all, SEB can be an appropriate candidate to decrease proliferation and survival rate of cancer cells and it can make noticeable alteration in expression of some genes in U266 cells and BM-MSCs. Further molecular studies are needed to identify the mechanism of action of SEB on U266 cells and BM-MSCs.
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نویسنده نفر چندم مقاله
علی قضاویچهارم
قاسم مسیبیپنجم

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Anti-cancer effects of Staphylococcal Enterotoxin type B on U266 cells co-cultured with Mesenchymal Stem Cells.pdfAnti-cancer effects of Staphylococcal Enterotoxin type B on U266 cells1396/10/17985981دانلود
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