Resveratrol decreases apoptosis and NLRP3 complex expressions in experimental varicocele rat model

Resveratrol decreases apoptosis and NLRP3 complex expressions in experimental varicocele rat model


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چکیده مقاله
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علوم پزشکی اراک
علوم پزشکی اراک

نویسندگان: فریده جلالی مشایخی , قاسم مسیبی , مریم باعزم , ادیب زنده دل , الناز حاجی پور

کلمات کلیدی: Keywords Author Keywords:Apoptosis; Inflammasomes; Resveratrol; Rat; Varicocele KeyWords Plus:SPINAL-CORD-INJURY; MALE-INFERTILITY; INFLAMMATION; INTERLEUKIN-6; PATHOGENESIS; PATHWAY; SIRT1

نشریه: Iranian Journal of Basic Medical Sciences, 2,,225 - 229,2018

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کد مقاله 4311
عنوان فارسی مقاله Resveratrol decreases apoptosis and NLRP3 complex expressions in experimental varicocele rat model
عنوان لاتین مقاله Resveratrol decreases apoptosis and NLRP3 complex expressions in experimental varicocele rat model
نوع مقاله بر حسب نگارش پژوهشی اصیل
مقاله برحسب نمایه ISI
IF 1.424
عنوان نشریه Iranian Journal of Basic Medical Sciences
نوع نشریه علمی پژوهشی
شماره نشریه 2
دوره 21
صفحه شروع و پایان در نشریه 225 - 229
سال انتشار/ ارائه شمسی 1396
سال انتشار/ارائه میلادی 2018
آدرس لینک مقاله/ همایش در شبکه اینترنت
ISSN 2008-3874
DOI
آدرس علمی (Affiliation) نویسنده متقاضی Department of Anatomy, School of Medicine, Arak University of Medical Sciences, Arak, Iran

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عنوان متن
چکیده انگلیسیAbstract Objective(s): Varicocele is an abnormal dilation in the testicular vein, which can cause hypoxia, reactive oxygen species accumulation, elevation in testicular temperature, and promote apoptosis and increase proinflammatory cytokine production. According to the varicocele pathophysiology, it is possible that a group of cytosolic receptors called nucleotide oligomerization domain (NOD)-like receptor family pyrin domain containing 3 (NLRP3) inflammasomes also involve in varicocele pathogenesis. Due to the important role of antioxidant in decreasing the testis tissue damage, in this study we investigated the protective effect of resveratrol (RES) on NLRP3 complex and apoptosis in experimental varicocele rats. Materials and Methods: In this study, 40 male Wistar rats were randomly divided into 5 groups (8 rats in each group): Control, experimental left varicocele (ELV), ELV + ethanol, ELV + 20 mg/kg RES and ELV + 50 mg/kg RES. Varicocele was induced by partial ligation of the left renal vein. Three months after varicocele induction, RESwas orally administered to rats for 1 month. The expression levels of NLRP3, apoptosis associated specklike protein (ASC), caspase-1, Bax and Bcl2 were analyzed using real time PCR. Results: Our results showed that RESat both doses significantly (P=0.05) decreased the gene expression levels of ASC, NLRP3, caspase-1 and Bax and increased Bcl2 gene expression at high dose. Conclusions: RESby reducing inflammatory factors and decreasing apoptosis might be used as adjuvant therapy to reduce varicocele complication.
چکیده
کلمات کلیدیKeywords Author Keywords:Apoptosis; Inflammasomes; Resveratrol; Rat; Varicocele KeyWords Plus:SPINAL-CORD-INJURY; MALE-INFERTILITY; INFLAMMATION; INTERLEUKIN-6; PATHOGENESIS; PATHWAY; SIRT1
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نویسنده نفر چندم مقاله
فریده جلالی مشایخیدوم
قاسم مسیبیسوم
مریم باعزمچهارم
ادیب زنده دلپنجم
الناز حاجی پوراول

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