Prediction of the Omp16 Epitopes for the Development of an Epitope-based Vaccine Against Brucellosis

Prediction of the Omp16 Epitopes for the Development of an Epitope-based Vaccine Against Brucellosis


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نویسندگان: حمید ابطحی

کلمات کلیدی: KEYWORDS: Brucella; Brucellosis; Epitope-based vaccine; Outer membrane protein 16(Omp16)

نشریه: Infectious Disorders - Drug Targets, 18,,1 - 10,2018

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کد مقاله 4486
عنوان فارسی مقاله Prediction of the Omp16 Epitopes for the Development of an Epitope-based Vaccine Against Brucellosis
عنوان لاتین مقاله Prediction of the Omp16 Epitopes for the Development of an Epitope-based Vaccine Against Brucellosis
نوع مقاله بر حسب نگارش مروری
مقاله برحسب نمایه PubMed.
IF
عنوان نشریه Infectious Disorders - Drug Targets
نوع نشریه علمی پژوهشی
شماره نشریه 18
دوره 18
صفحه شروع و پایان در نشریه 1 - 10
سال انتشار/ ارائه شمسی 1397
سال انتشار/ارائه میلادی 2018
آدرس لینک مقاله/ همایش در شبکه اینترنت
ISSN 2212-3989
DOI DOI: 10.2174/1871526518666180709121653
آدرس علمی (Affiliation) نویسنده متقاضی Molecular and Medicine Research Center, Arak University of Medical Science, Arak, Islamic Republic of IRAN

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چکیده انگلیسیAbstract Brucellosis is an infectious disease caused by Brucella bacteria that cause disease in animals and humans. Brucellosis is one of the most common zoonotic diseases transmitted animals -to-human through direct contact with infected animals and also consumption of unpasteurized dairy products. Due to wide incidence of brucellosis in Iran and economical costs in industry animal husbandry, Vaccination is best way to prevent of this disease. All of available commercial vaccines against brucellosis are derived from live attenuated strains of Brucella. But because of disadvantage of live attenuated vaccines, protective subunit vaccine against Brucella may be a good candidate for production of new recombinant vaccines based on Brucella outer membrane protein (OMP) antigens. In the present study, comprehensive bioinformatics analysis has been conducted on prediction software to predict T and B cell epitopes, the secondary and tertiary structures and antigenicity of Omp16 antigen and the validation of used software confirmed by experimental results. The final epitope prediction results have proposed that the three epitopes were predicted for the Omp16 protein with antigenicity ability. We hypothesized that these epitopes likely have protective capacity to stimulate both the B-cell and T-cell mediated immune responses and so may be effective as an immunogenic candidate for the development of an epitope-based vaccine against brucellosis.
چکیده
کلمات کلیدیKEYWORDS: Brucella; Brucellosis; Epitope-based vaccine; Outer membrane protein 16(Omp16)
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نویسنده نفر چندم مقاله
حمید ابطحیپنجم

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Mohammad Rabbani-khorasgani-MS.pdf 1397/07/02861088دانلود