Dkk-3 as a potential biomarker for diagnosis and prognosis of colorectal cancer

Dkk-3 as a potential biomarker for diagnosis and prognosis of colorectal cancer


چاپ صفحه
پژوهان
صفحه نخست سامانه
چکیده مقاله
چکیده مقاله
نویسندگان
نویسندگان
دانلود مقاله
دانلود مقاله
علوم پزشکی اراک
علوم پزشکی اراک

نویسندگان: قاسم مسیبی , سمانه خرمی

کلمات کلیدی: Keywords: Dkk-3, Colorectal cancer, Biomarker

نشریه: Medical Journal of the Islamic Republic of Iran, 32,,502 - 506,2018

اطلاعات کلی مقاله
hide/show

کد مقاله 4603
عنوان فارسی مقاله Dkk-3 as a potential biomarker for diagnosis and prognosis of colorectal cancer
عنوان لاتین مقاله Dkk-3 as a potential biomarker for diagnosis and prognosis of colorectal cancer
نوع مقاله بر حسب نگارش پژوهشی اصیل
مقاله برحسب نمایه PubMed.
IF
عنوان نشریه Medical Journal of the Islamic Republic of Iran
نوع نشریه علمی پژوهشی
شماره نشریه 32
دوره 86
صفحه شروع و پایان در نشریه 502 - 506
سال انتشار/ ارائه شمسی 1397
سال انتشار/ارائه میلادی 2018
آدرس لینک مقاله/ همایش در شبکه اینترنت http://mjiri.iums.ac.ir/browse.php?mag_id=111&slc_lang=en&sid=1
ISSN 1016-1430
DOI
آدرس علمی (Affiliation) نویسنده متقاضی 1Molecular and Medicine Research Center (MMRC), Department of Microbiology and Immunology,

چکیده مقاله
hide/show

عنوان متن
چکیده انگلیسیAbstract Background: The Dickkopf 3 (Dkk-3) protein is a member of the Dkk family known as Wnt signaling inhibitor. The level of DKk-3 changes in a wide range of cancers, such as colorectal cancer, lung cancer, prostate cancer, and bladder cancer, is proposed as a biomarker for diagnosis and prognosis of many cancers. The present study was conducted to evaluate the serum level of Dkk-3 as a cancer biomarker and to determine their prognostic value in colorectal cancer (CRC) patients and healthy matched controls. Methods: A total of 30 colorectal cancer patients at different stages of the disease and healthy matched controls with no history of inflammatory and autoimmune disease or cancer were enrolled in the study. The level of Dkk-3 was assessed serologically using enzymelinked immunosorbent assay (ELISA) method, moreover, relevance of these markers with patients’ clinicopathological features was subsequently assessed. Means comparison and ROC curves analysis were done using SPSS software. P-value ˂0.05 was considered significant in all the tests. Results: In this study, it was revealed that serum level of Dkk-3 was significantly (p<0.001) lower in patients compared to the healthy controls. Statistical analysis showed that serum level of Dkk-3 has 78% specificity and 77% sensitivity (AUC= 0.782, 95% CI) for diagnosis of colorectal cancer. Conclusion: Dkk-3 protein can be considered as a potential biomarker for diagnosis and possibly the prognosis of colorectal cancer.
چکیده
کلمات کلیدیKeywords: Dkk-3, Colorectal cancer, Biomarker
نام فایل عنوان پیوست تاریخ درج فایل اندازه فایل دانلود

نویسندگان
hide/show

نویسنده نفر چندم مقاله
قاسم مسیبیدوم و مسئول
سمانه خرمیسوم

لینک دانلود مقاله
hide/show

نام فایل عنوان پیوست تاریخ درج فایل اندازه فایل دانلود
Dkk3 and beast cancer MJIRI-v32n1p502-en AZAR 97 .pdfمتن کامل مقاله1397/09/28677955دانلود
MJIRI.pdf 1397/09/28200426دانلود
Medical journal of the Islamic Republic of Iran IF.pdf 1397/09/28402466دانلود