Sesame seeds essential oil and Sesamol modulate the pro-inflammatory function of macrophages and dendritic cells and promote Th2 response

Sesame seeds essential oil and Sesamol modulate the pro-inflammatory function of macrophages and dendritic cells and promote Th2 response


چاپ صفحه
پژوهان
صفحه نخست سامانه
چکیده مقاله
چکیده مقاله
نویسندگان
نویسندگان
دانلود مقاله
دانلود مقاله
علوم پزشکی اراک
علوم پزشکی اراک

نویسندگان: قاسم مسیبی , سمانه خرمی

کلمات کلیدی: Keywords: Sesame, Sesamol, Splenocyte, Macrophage, Nitric oxide, Dendritic cells

نشریه: Medical Journal of The Islamic Republic of Iran, 1,,566 - 573,2018

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کد مقاله 4604
عنوان فارسی مقاله Sesame seeds essential oil and Sesamol modulate the pro-inflammatory function of macrophages and dendritic cells and promote Th2 response
عنوان لاتین مقاله Sesame seeds essential oil and Sesamol modulate the pro-inflammatory function of macrophages and dendritic cells and promote Th2 response
نوع مقاله بر حسب نگارش پژوهشی اصیل
مقاله برحسب نمایه PubMed.
IF 0.0
عنوان نشریه Medical Journal of The Islamic Republic of Iran
نوع نشریه علمی پژوهشی
شماره نشریه 1
دوره 32
صفحه شروع و پایان در نشریه 566 - 573
سال انتشار/ ارائه شمسی 1397
سال انتشار/ارائه میلادی 2018
آدرس لینک مقاله/ همایش در شبکه اینترنت http://mjiri.iums.ac.ir/browse.php?mag_id=111&slc_lang=en&sid=1
ISSN 1016-1430
DOI
آدرس علمی (Affiliation) نویسنده متقاضی 1Molecular and Medicine Research Center (MMRC), Department of Microbiology and Immunology,

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عنوان متن
چکیده انگلیسیBackground: Herbal medicine is becoming progressively accepted treatment for management of different diseases worldwide. Recognition of the active ingredients and mechanisms of herbal medicine against the immune system and related anomalies is highly favorable. This experimental study aimed to investigate the effects of Sesame (Sesamum indicum L.) essential oil and sesamol as effective components on mouse splenocytes subsets, macrophages and dendritic cells (DCs). Methods: Effective components of sesame were extracted and used to treat splenocytes, PHA (5μg/ml) and LPS (10 μg/ml) stimulated splenocytes, macrophages and DCs in different concentration (0.01–100 μg/ml). The cell proliferation/viability was measured using the MTT assay and nitrite levels were measured by the diazotization method. Moreover, TNF-α and IL-1β cytokines concentration were assayed by ELISA. Treated DCs also analysed for maturation marker levels and cytokine production. Results: Analysis of the results indicated that sesame components suppress PHA-stimulated splenocytes with no effect on LPS-stimulated subsets. Furthermore, the sesame ingredients reduced the release of IFN-γ and increased secretion of IL-4 from lymphocytes. Macrophages viability was not affected and production of NO, TNF-α, and IL-1β were inhibited using sesame essential oil and sesamol. DCs phenotype skewed to immature and release of TNF-α and IL-1β were abrogated form DCs. Conclusion: These results indicate that sesame essential oil and its effective component as sesamol may capable of suppressing the response of cellular immunity with the domination of Th2 responses and also could modulate macrophages and the dendritic cells pro-inflammatory functions
چکیده
کلمات کلیدیKeywords: Sesame, Sesamol, Splenocyte, Macrophage, Nitric oxide, Dendritic cells
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نویسنده نفر چندم مقاله
قاسم مسیبیسوم و مسئول
سمانه خرمیاول

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Sesame oil and macrophage MJIRI-v32n1p566-en AZAR 97.pdfمتن کامل مقاله1397/09/281758101دانلود
Medical journal of the Islamic Republic of Iran IF.pdf 1397/09/28402466دانلود
MJIRI.pdf 1397/09/28200426دانلود